Today, global landfill sites are piled with increasing quantities of heterogeneous material waste that cannot simply ‘return to the soil.’ This has brought into sharp focus the insufficiency of contemporary value paradigms governing the design and management of today’s materials. Given soil health is defined as the continued capacity of soil to function as a living and life-giving ecosystem that sustains plants, animals and humans, Soil Sisters, a research and design practice based at the Yale Center for Ecosystems in Architecture, is based on integrated material life cycle and ecosystems design that supports near- to long-term soil health. Defined by the bottom-up identification of material life cycle gaps and opportunities for unalienating value leading to just labor, environmental health outcomes and value chain development outcomes, the underlying processes of Soil Sisters practices are ‘generative.’ In contrast to the sole focus on biobased materials that prioritize the sources of materials from biogenic sources, Soil Sister materials prioritize where materials are going, in terms of timely and nontoxic soil degradation. The Soil Sisters Material Library includes a broad range of biobased, mineral and synthetic material products grouped into four initial classes of Soil Sister products including “material bank,” “nontoxic circular,” “carbon sink” and “regenerative” materials.